GTF2F1 Antibody, HRP conjugated

1. An AR motif of the transactivation domain has been identified that contributes to transcriptional activity by recruiting the C-terminal domain of subunit 1 of the general transcription regulator TFIIF. PMID: 29225078
2. These results suggest that Mediator structural shifts induced by activator binding help stably orient pol II prior to transcription initiation within the human mediator-RNA polymerase II-TFIIF assembly. PMID: 22343046
3. Gdown1 competes with TFIIF for binding to the RPB1 and RPB5 subunits of Pol II, thereby inhibiting an essential function of TFIIF in preinitiation complex assembly. PMID: 22244332
4. role of associated carboxyl-terminal domain phosphatase in dephosphorylating phosphoserines 2 and 5 of RNA polymerase II PMID: 12351650
5. The alpha 1 helix of human RAP74 has an important role in the initiation and elongation of RNA chains PMID: 12354769
6. The NMR solution structure of the C-terminal domain of RAP74 has been determined, and NMR methods have been used to map the binding sites of the C-terminus of CTD phosphatase/FCP1 on the RAP74 C-terminal fragment. PMID: 12578358
7. cocrystal structure of the winged-helix domain of human RNA polymerase II-associating protein 74 bound to the alpha-helical C terminus of human FCP1 PMID: 12591941
8. NMR structure of a complex containing this TFIIF subunit and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. PMID: 12732728
9. Interaction of TFIIF subunit RAP74 with recombinant androgen receptor N-terminal activation domain AF1 leads to imposition of helical structure on the AF1 domain. PMID: 15023052
10. TFIIF supports elongation and suppresses pausing by stabilizing the post-translocated elongation complex PMID: 15351637
11. alpha1-Helix of RAP74 is important for supporting NTP-driven translocation by RNAP II. PMID: 15831464
12. TFIIF and Rpb7 are involved in both early and late transcriptional stages PMID: 17848138
13. Mutated hydrophobic residues in RAP74 C-terminal structure disrupt secondary structure elements, showing that binding of the androgen receptor N-terminal domain depends upon helix 3 in the winged-helix domain of the RAP74 C-terminal domain polypeptide. PMID: 18284209
14. NMR and thermodynamic studies further elucidate the complex molecular mechanism by which TFIIF and FCP1 cooperate for RNAPII recycling. PMID: 19215094

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HGNC: 4652

OMIM: 189968

KEGG: hsa:2962

STRING: 9606.ENSP00000377969

UniGene: Hs.68257